Shortening the Lipid A Acyl Chains of <i>Bordetella pertussis </i>Enables Depletion of Lipopolysaccharide Endotoxic Activity

Whooping cough, or pertussis, is an acute respiratory infectious disease caused by the Gram-negative bacterium <i>Bordetella pertussis.</i> Whole-cell vaccines, which were introduced in the fifties of the previous century and proved to be effective, showed considerable reactogenicity and...

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Библиографические подробности
Главные авторы: Jesús Arenas, Elder Pupo, Coen Phielix, Dionne David, Afshin Zariri, Alla Zamyatina, Jan Tommassen, Peter van der Ley
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2020-10-01
Серии:Vaccines
Предметы:
<i>Bordetella pertussis</i>
LPS
lipid A engineering
endotoxin
whole-cell vaccine
reactogenicity
Online-ссылка:https://www.mdpi.com/2076-393X/8/4/594
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