Expression of the Lipopolysaccharide-Modifying Enzymes PagP and PagL Modulates the Endotoxic Activity of Bordetella pertussis

Lipopolysaccharide (LPS) is one of the major constituents of the gram-negative bacterial cell envelope. Its endotoxic activity causes the relatively high reactogenicity of whole-cell vaccines. Several bacteria harbor LPS-modifying enzymes that modulate the endotoxic activity of the LPS. Here we eval...

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Detalhes bibliográficos
Main Authors: Geurtsen, Jeroen, Steeghs, Liana, Hamstra, Hendrik-Jan, ten Hove, Jan, de Haan, Alex, Kuipers, Betsy, Tommassen, Jan, van der Ley, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1594925/
https://ncbi.nlm.nih.gov/pubmed/16988232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00834-06
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