Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa

Pathogenic Gram-negative bacteria can modify the lipid A portion of their lipopolysaccharide in response to environmental stimuli. 3-O-deacylation of lipid A by the outer membrane enzyme PagL modulates signaling through Toll-like receptor 4, leading to a reduced host immune response. We found that P...

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Hlavní autoři: Rutten, Lucy, Geurtsen, Jeroen, Lambert, Wietske, Smolenaers, Jeroen J. M., Bonvin, Alexandre M., de Haan, Alex, van der Ley, Peter, Egmond, Maarten R., Gros, Piet, Tommassen, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564273/
https://ncbi.nlm.nih.gov/pubmed/16632613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509392103
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