Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium

The lipid A portion of lipopolysaccharide, the major component of the outer leaflet of the outer membrane of Gram-negative bacteria, is toxic to humans. Modification of lipid A by enzymes often reduces its toxicity. The outer-membrane protein LpxR from Salmonella typhimurium is a lipid A-modifying e...

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Detalhes bibliográficos
Main Authors: Rutten, Lucy, Mannie, Jean-Paul B. A., Stead, Christopher M., Raetz, Christian R. H., Reynolds, C. Michael, Bonvin, Alexandre M. J. J., Tommassen, Jan P., Egmond, Maarten R., Trent, M. Stephen, Gros, Piet
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644146/
https://ncbi.nlm.nih.gov/pubmed/19174515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813064106
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