Identification of a Novel Lipopolysaccharide Core Biosynthesis Gene Cluster in Bordetella pertussis, and Influence of Core Structure and Lipid A Glucosamine Substitution on Endotoxic Activity

Lipopolysaccharide (LPS), also known as endotoxin, is one of the main constituents of the gram-negative bacterial outer membrane. Whereas the lipid A portion of LPS is generally considered the main determinant for endotoxic activity, the oligosaccharide moiety plays an important role in immune evasi...

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Detalhes bibliográficos
Main Authors: Geurtsen, Jeroen, Dzieciatkowska, Monika, Steeghs, Liana, Hamstra, Hendrik-Jan, Boleij, Johanna, Broen, Kelly, Akkerman, Grietsje, el Hassan, Hassan, Li, Jianjun, Richards, James C., Tommassen, Jan, van der Ley, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708539/
https://ncbi.nlm.nih.gov/pubmed/19364841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00033-09
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