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Lipopolysaccharide Engineering in Neisseria meningitidis: STRUCTURAL ANALYSIS OF DIFFERENT PENTAACYL LIPID A MUTANTS AND COMPARISON OF THEIR MODIFIED AGONIST PROPERTIES
Engineering the lipopolysaccharide (LPS) biosynthetic pathway offers the potential to obtain modified derivatives with optimized adjuvant properties. Neisseria meningitidis strain H44/76 was modified by expression of the pagL gene encoding lipid A 3-O-deacylase from Bordetella bronchiseptica and by...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3961689/ https://ncbi.nlm.nih.gov/pubmed/24492609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.554345 |
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