Naturally Occurring Lipid A Mutants in Neisseria meningitidis from Patients with Invasive Meningococcal Disease Are Associated with Reduced Coagulopathy

Neisseria meningitidis is a major cause of bacterial meningitis and sepsis worldwide. Lipopolysaccharide (LPS), a major component of the Gram-negative bacterial outer membrane, is sensed by mammalian cells through Toll-like receptor 4 (TLR4), resulting in activation of proinflammatory cytokine pathw...

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Main Authors: Fransen, Floris, Heckenberg, Sebastiaan G. B., Hamstra, Hendrik Jan, Feller, Moniek, Boog, Claire J. P., van Putten, Jos P. M., van de Beek, Diederik, van der Ende, Arie, van der Ley, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667671/
https://ncbi.nlm.nih.gov/pubmed/19390612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000396
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