Meningococcal factor H binding protein fHbpd184 polymorphism influences clinical course of meningococcal meningitis.

Factor H Binding protein (fHbp) is an important meningococcal virulence factor, enabling the meningococcus to evade the complement system, and a main target for vaccination. Recently, the structure of fHBP complexed with factor H (fH) was published. Two fHbp glutamic acids, E(283) and E(304), form s...

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Autori principali: Jurgen R Piet, Matthijs C Brouwer, Rachel Exley, Stijn van der Veen, Diederik van de Beek, Arie van der Ende
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2012-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC3479137?pdf=render
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