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IFN-γ limits Th9 mediated autoimmune inflammation through dendritic cell modulation of IL-27

IL-9 producing Th9 cells have been associated with autoimmune diseases, such as experimental autoimmune encephalitis. However, the factors that negatively regulate Th9 cells during autoimmune inflammation are unclear. Here we show that IFN-γ inhibits Th9 differentiation both in vitro and in vivo. Th...

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Autores principales: Murugaiyan, Gopal, Beynon, Vanessa, da Cunha, Andre Pires, Joller, Nicole, Weiner, Howard L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504131/
https://ncbi.nlm.nih.gov/pubmed/23125412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200808
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