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IL-27 induction of IL-21 from human CD8(+) T cells induces granzyme B in an autocrine manner

Interleukin (IL)-27 exerts an anti-inflammatory effect on human and mice CD4(+) T cells by inducing IL-10-producing T regulatory 1 cells through induction of IL-21. However, the role of IL-27 and how it regulates IL-21 from human CD8(+) T cells is unclear. Here, we show that the IL-27 receptor is ex...

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Detalhes bibliográficos
Publicado no:Immunol Cell Biol
Main Authors: Mittal, Akanksha, Murugaiyan, Gopal, Beynon, Vanessa, Hu, Dan, Weiner, Howard L
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293547/
https://ncbi.nlm.nih.gov/pubmed/22430249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2012.14
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