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IFN-γ limits Th9 mediated autoimmune inflammation through dendritic cell modulation of IL-27

IL-9 producing Th9 cells have been associated with autoimmune diseases, such as experimental autoimmune encephalitis. However, the factors that negatively regulate Th9 cells during autoimmune inflammation are unclear. Here we show that IFN-γ inhibits Th9 differentiation both in vitro and in vivo. Th...

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Detalhes bibliográficos
Main Authors: Murugaiyan, Gopal, Beynon, Vanessa, da Cunha, Andre Pires, Joller, Nicole, Weiner, Howard L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504131/
https://ncbi.nlm.nih.gov/pubmed/23125412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200808
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