Identification and Characterization of a Compound That Protects Cardiac Tissue from Human Ether-à-go-go-related Gene (hERG)-related Drug-induced Arrhythmias

The human Ether-à-go-go-related gene (hERG)-encoded K(+) current, I(Kr) is essential for cardiac repolarization but is also a source of cardiotoxicity because unintended hERG inhibition by diverse pharmaceuticals can cause arrhythmias and sudden cardiac death. We hypothesized that a small molecule t...

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Main Authors: Potet, Franck, Lorinc, Amanda N., Chaigne, Sebastien, Hopkins, Corey R., Venkataraman, Raghav, Stepanovic, Svetlana Z., Lewis, L. Michelle, Days, Emily, Sidorov, Veniamin Y., Engers, Darren W., Zou, Beiyan, Afshartous, David, George, Alfred L., Campbell, Courtney M., Balser, Jeffrey R., Li, Min, Baudenbacher, Franz J., Lindsley, Craig W., Weaver, C. David, Kupershmidt, Sabina
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
主題:
Membrane Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501040/
https://ncbi.nlm.nih.gov/pubmed/23033485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.380162
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