Identification and Characterization of a Compound That Protects Cardiac Tissue from Human Ether-à-go-go-related Gene (hERG)-related Drug-induced Arrhythmias

The human Ether-à-go-go-related gene (hERG)-encoded K(+) current, I(Kr) is essential for cardiac repolarization but is also a source of cardiotoxicity because unintended hERG inhibition by diverse pharmaceuticals can cause arrhythmias and sudden cardiac death. We hypothesized that a small molecule t...

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Bibliografische gegevens
Hoofdauteurs: Potet, Franck, Lorinc, Amanda N., Chaigne, Sebastien, Hopkins, Corey R., Venkataraman, Raghav, Stepanovic, Svetlana Z., Lewis, L. Michelle, Days, Emily, Sidorov, Veniamin Y., Engers, Darren W., Zou, Beiyan, Afshartous, David, George, Alfred L., Campbell, Courtney M., Balser, Jeffrey R., Li, Min, Baudenbacher, Franz J., Lindsley, Craig W., Weaver, C. David, Kupershmidt, Sabina
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2012
Onderwerpen:
Membrane Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501040/
https://ncbi.nlm.nih.gov/pubmed/23033485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.380162
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