Identification and Characterization of a Compound That Protects Cardiac Tissue from Human Ether-à-go-go-related Gene (hERG)-related Drug-induced Arrhythmias

The human Ether-à-go-go-related gene (hERG)-encoded K(+) current, I(Kr) is essential for cardiac repolarization but is also a source of cardiotoxicity because unintended hERG inhibition by diverse pharmaceuticals can cause arrhythmias and sudden cardiac death. We hypothesized that a small molecule t...

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Detalhes bibliográficos
Main Authors: Potet, Franck, Lorinc, Amanda N., Chaigne, Sebastien, Hopkins, Corey R., Venkataraman, Raghav, Stepanovic, Svetlana Z., Lewis, L. Michelle, Days, Emily, Sidorov, Veniamin Y., Engers, Darren W., Zou, Beiyan, Afshartous, David, George, Alfred L., Campbell, Courtney M., Balser, Jeffrey R., Li, Min, Baudenbacher, Franz J., Lindsley, Craig W., Weaver, C. David, Kupershmidt, Sabina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501040/
https://ncbi.nlm.nih.gov/pubmed/23033485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.380162
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