1,3-BUTADIENE: BIOMARKERS AND APPLICATION TO RISK ASSESSMENT

1,3-Butadiene (BD) is a known rodent and human carcinogen that is metabolized mainly by P450 2E1 to three epoxides, 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB) and 1,2-epoxy-3,4-butanediol (EB-diol). The individual epoxides vary up to 200-fold in their mutagenic potency, with DEB being the...

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Bibliografiske detaljer
Main Authors: Swenberg, James A., Bordeerat, Narisa K., Boysen, Gunnar, Carro, Sujey, Georgieva, Nadia I., Nakamura, Jun, Troutman, John M., Upton, Patricia B., Albertini, Richard J., Vacek, Pamela M., Walker, Vernon E., Sram, Radim J., Goggin, Melissa, Tretyakova, Natalia
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501005/
https://ncbi.nlm.nih.gov/pubmed/20974116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2010.10.010
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