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Exposure-Response of 1,2:3,4-Diepoxybutane–Specific N-Terminal Valine Adducts in Mice and Rats after Inhalation Exposure to 1,3-Butadiene

1,3-Butadiene (BD) is a known rodent and human carcinogen that is metabolized mainly by P450 2E1 to three epoxides, 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 1,2-epoxy-3,4-butanediol. The individual epoxides vary up to 200-fold in their mutagenic potency, with DEB being the most muta...

詳細記述

保存先:
書誌詳細
主要な著者: Georgieva, Nadia I., Boysen, Gunnar, Bordeerat, Narisa, Walker, Vernon E., Swenberg, James A.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871755/
https://ncbi.nlm.nih.gov/pubmed/20176624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq060
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