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Molecular dosimetry of 1, 2, 3, 4-diepoxybutane induced DNA-DNA crosslinks in B6C3F1 mice and F344 rats exposed to 1,3-butadiene by inhalation
1,3-butadiene (BD) is an important industrial and environmental chemical classified as a human carcinogen based on epidemiological studies in occupationally exposed workers and animal studies in laboratory rats and mice. BD is metabolically activated to three epoxides that can react with nucleophili...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2828062/ https://ncbi.nlm.nih.gov/pubmed/19276346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4152 |
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