1,3-BUTADIENE: BIOMARKERS AND APPLICATION TO RISK ASSESSMENT

1,3-Butadiene (BD) is a known rodent and human carcinogen that is metabolized mainly by P450 2E1 to three epoxides, 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB) and 1,2-epoxy-3,4-butanediol (EB-diol). The individual epoxides vary up to 200-fold in their mutagenic potency, with DEB being the...

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Hauptverfasser: Swenberg, James A., Bordeerat, Narisa K., Boysen, Gunnar, Carro, Sujey, Georgieva, Nadia I., Nakamura, Jun, Troutman, John M., Upton, Patricia B., Albertini, Richard J., Vacek, Pamela M., Walker, Vernon E., Sram, Radim J., Goggin, Melissa, Tretyakova, Natalia
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501005/
https://ncbi.nlm.nih.gov/pubmed/20974116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2010.10.010
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