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Inhibition of Bupropion Metabolism by Selegiline: Mechanism-Based Inactivation of Human CYP2B6 and Characterization of Glutathione and Peptide Adducts

Selegiline, the R-enantiomer of deprenyl, is used in the treatment of Parkinson's disease. Bupropion, an antidepressant, often used to treat patients in conjunction with selegiline, is metabolized primarily by CYP2B6. The effect of selegiline on the enzymatic activity of human cytochrome CYP2B6...

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書誌詳細
主要な著者: Sridar, Chitra, Kenaan, Cesar, Hollenberg, Paul F.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500550/
https://ncbi.nlm.nih.gov/pubmed/22936314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.046979
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