טוען...
Roles of Residues F206 and V367 in Human CYP2B6: Effects of Mutations on Androgen Hydroxylation, Mechanism-Based Inactivation, and Reversible Inhibition
The crystal structures of human CYP2B6 indicate that Phe206 and Val367 are in close proximity to the substrate binding site and suggest that both residues may play important roles in substrate metabolism and inhibitor binding. To test this hypothesis, we investigated the effects of mutating these re...
שמור ב:
| הוצא לאור ב: | Drug Metab Dispos |
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| Main Authors: | , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
The American Society for Pharmacology and Experimental Therapeutics
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5074475/ https://ncbi.nlm.nih.gov/pubmed/27538916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.071662 |
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