Mechanism-Based Inactivation of CYP2B1 and Its F-Helix Mutant by Two tert-Butyl Acetylenic Compounds: Covalent Modification of Prosthetic Heme Versus Apoprotein

The mechanism-based inactivation of cytochrome CYP2B1 [wild type (WT)] and its Thr205 to Ala mutant (T205A) by tert-butylphenylacetylene (BPA) and tert-butyl 1-methyl-2-propynyl ether (BMP) in the reconstituted system was investigated. The inactivation of WT by BPA exhibited a k(inact)/K(I) value of...

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Bibliografiska uppgifter
Huvudupphovsmän: Lin, Hsia-lien, Zhang, Haoming, Noon, Kathleen R., Hollenberg, Paul F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2009
Ämnen:
Metabolism, Transport, and Pharmacogenomics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775271/
https://ncbi.nlm.nih.gov/pubmed/19700628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.158782
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