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Formation of Both Heme and Apoprotein Adducts Contributes to the Mechanism-Based Inactivation of Human CYP2J2 by 17α-Ethynylestradiol

17α-Ethynylestradiol (EE), a major component of many oral contraceptives, affects the activities of a number of the human cytochrome P450 (P450) enzymes. Here, we characterized the effect of EE on CYP2J2, a major human P450 isoform that participates in metabolism of arachidonic acid. EE inactivated...

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Bibliographic Details
Published in:Drug Metab Dispos
Main Authors: Lin, Hsia-lien, Zhang, Haoming, Hollenberg, Paul F.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931439/
https://ncbi.nlm.nih.gov/pubmed/29602797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.080903
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