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The Effect of Ritonavir on Human CYP2B6 Catalytic Activity: Heme Modification Contributes to the Mechanism-Based Inactivation of CYP2B6 and CYP3A4 by Ritonavir
The mechanism-based inactivation of human CYP2B6 by ritonavir (RTV) in a reconstituted system was investigated. The inactivation is time, concentration, and NADPH dependent and exhibits a K(I) of 0.9 μM, a k(inact) of 0.05 min(−1), and a partition ratio of approximately 3. Liquid chromatography–tand...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3781371/ https://ncbi.nlm.nih.gov/pubmed/23886699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.053108 |
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