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Mechanism-Based Inactivation of Human CYP2E1 by Diethyldithocarbamate
Although the ability of disulfiram to inactivate CYP2E1 has been known for more than 20 years, the mechanism has not yet been elucidated. A metabolite of disulfiram, diethyldithocarbamate (DDC), is converted by CYP2E1 to a reactive intermediate that subsequently inactivates the protein, leading to m...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2993453/ https://ncbi.nlm.nih.gov/pubmed/20826547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.034710 |
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