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Mechanism-Based Inactivation of Human CYP2E1 by Diethyldithocarbamate

Although the ability of disulfiram to inactivate CYP2E1 has been known for more than 20 years, the mechanism has not yet been elucidated. A metabolite of disulfiram, diethyldithocarbamate (DDC), is converted by CYP2E1 to a reactive intermediate that subsequently inactivates the protein, leading to m...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pratt-Hyatt, Matthew, Lin, Hsia-lien, Hollenberg, Paul F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993453/
https://ncbi.nlm.nih.gov/pubmed/20826547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.034710
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