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Roles of Residues F206 and V367 in Human CYP2B6: Effects of Mutations on Androgen Hydroxylation, Mechanism-Based Inactivation, and Reversible Inhibition

The crystal structures of human CYP2B6 indicate that Phe206 and Val367 are in close proximity to the substrate binding site and suggest that both residues may play important roles in substrate metabolism and inhibitor binding. To test this hypothesis, we investigated the effects of mutating these re...

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發表在:Drug Metab Dispos
Main Authors: Lin, Hsia-lien, Zhang, Haoming, Kenaan, Cesar, Hollenberg, Paul F.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074475/
https://ncbi.nlm.nih.gov/pubmed/27538916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.071662
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