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A Quantitative High-Throughput 96-well plate Fluorescence Assay for Mechanism-Based Inactivators of Cytochromes P450 Exemplified using CYP2B6

Mechanism-based inactivators such as bergamottin are useful chemical tools for identifying the roles of specific active-site amino acid residues in the reactions catalyzed by the cytochromes P450 (CYPs or P450s) that are responsible for the metabolism of a wide variety of drugs and endogenous substr...

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Detalhes bibliográficos
Main Authors: Kenaan, Cesar, Zhang, Haoming, Hollenberg, Paul F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967228/
https://ncbi.nlm.nih.gov/pubmed/20885377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2010.125
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