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UNCOVERING THE ROLE OF HYDROPHOBIC RESIDUES IN CYTOCHROME P450-CYTOCHROME P450 REDUCTASE INTERACTIONS
Cytochrome P450 (CYP or P450)-mediated drug metabolism requires the interaction of P450s with their redox partner, cytochrome P450 reductase (CPR). In this work, we have investigated the role of P450 hydrophobic residues in complex formation with CPR and uncovered novel roles for the surface-exposed...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3102249/ https://ncbi.nlm.nih.gov/pubmed/21462923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1020748 |
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