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Inhibition of Bupropion Metabolism by Selegiline: Mechanism-Based Inactivation of Human CYP2B6 and Characterization of Glutathione and Peptide Adducts

Selegiline, the R-enantiomer of deprenyl, is used in the treatment of Parkinson's disease. Bupropion, an antidepressant, often used to treat patients in conjunction with selegiline, is metabolized primarily by CYP2B6. The effect of selegiline on the enzymatic activity of human cytochrome CYP2B6...

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Bibliografske podrobnosti
Main Authors: Sridar, Chitra, Kenaan, Cesar, Hollenberg, Paul F.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3500550/
https://ncbi.nlm.nih.gov/pubmed/22936314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.046979
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