Polymorphic Variants of Cytochrome P450 2B6 (CYP2B6.4–CYP2B6.9) Exhibit Altered Rates of Metabolism for Bupropion and Efavirenz: A Charge-Reversal Mutation in the K139E Variant (CYP2B6.8) Impairs Formation of a Functional Cytochrome P450-Reductase Complex

In this study, metabolism of bupropion, efavirenz, and 7-ethoxy-4-trifluoromethylcoumarin (7-EFC) by CYP2B6 wild type (CYP2B6.1) and six polymorphic variants (CYP2B6.4 to CYP2B6.9) was investigated in a reconstituted system to gain a better understanding of the effects of the mutations on the cataly...

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Bibliographic Details
Main Authors: Zhang, Haoming, Sridar, Chitra, Kenaan, Cesar, Amunugama, Hemali, Ballou, David P., Hollenberg, Paul F.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2011
Subjects:
Metabolism, Transport, and Pharmacogenomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164347/
https://ncbi.nlm.nih.gov/pubmed/21659470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.183111
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