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Mechanism-Based Inactivation of Cytochrome P450 2B6 by Methadone through Destruction of Prosthetic Heme

Methadone is a μ-opioid receptor agonist widely used in the treatment of narcotic addiction and chronic pain conditions. Methadone is metabolized predominantly in the liver by cytochromes P450 to its pharmacologically inactive primary metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine. Ini...

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Sonraí Bibleagrafaíochta
Main Authors: Amunugama, Hemali T., Zhang, Haoming, Hollenberg, Paul F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422545/
https://ncbi.nlm.nih.gov/pubmed/22685215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.045971
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