Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants

Bioactivation of the antidepressant and smoking cessation drug bupropion is catalyzed predominantly by CYP2B6. The metabolite hydroxybupropion derived from t-butylhydroxylation is considered to contribute to the antidepressant and smoking-cessation effects of the parent drug. Bupropion hydroxylation...

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Bibliographic Details
Published in:Drug Metab Dispos
Main Authors: Wang, Pan-Fen, Neiner, Alicia, Kharasch, Evan D.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228493/
https://ncbi.nlm.nih.gov/pubmed/32238417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.090407
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