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Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants

Bioactivation of the antidepressant and smoking cessation drug bupropion is catalyzed predominantly by CYP2B6. The metabolite hydroxybupropion derived from t-butylhydroxylation is considered to contribute to the antidepressant and smoking-cessation effects of the parent drug. Bupropion hydroxylation...

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Bibliografische gegevens
Gepubliceerd in:Drug Metab Dispos
Hoofdauteurs: Wang, Pan-Fen, Neiner, Alicia, Kharasch, Evan D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228493/
https://ncbi.nlm.nih.gov/pubmed/32238417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.090407
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