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Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry
Efavirenz (more specifically the S-enantiomer) is a cornerstone antiretroviral therapy for treatment of HIV infection. The major primary metabolite is S-8-hydroxyefavirenz, which does not have antiretroviral activity but is neurotoxic. Cytochrome P450 2B6 (CYP2B6) is the major enzyme catalyzing S-8-...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Drug Metab Dispos |
|---|---|
| Prif Awduron: | , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6756292/ https://ncbi.nlm.nih.gov/pubmed/31324697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.086348 |
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