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Common polymorphisms of CYP2B6 influence stereoselective bupropion disposition

Bupropion hydroxylation is a bioactivation and metabolic pathway, and the standard clinical CYP2B6 probe. This investigation determined the influence of CYP2B6 allelic variants on clinical concentrations and metabolism of bupropion enantiomers. Secondary objectives evaluated the influence of CYP2C19...

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Bibliographic Details
Published in:Clin Pharmacol Ther
Main Authors: Kharasch, Evan D., Crafford, Amanda
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927671/
https://ncbi.nlm.nih.gov/pubmed/29756345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1116
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