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Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids

Gymnosis is the process of the delivery of antisense oligodeoxynucleotides to cells, in the absence of any carriers or conjugation, that produces sequence-specific gene silencing. While gymnosis was originally demonstrated using locked nucleic acid (LNA) gapmers, 2′-deoxy-2′fluoroarabino nucleic aci...

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Bibliografiske detaljer
Main Authors: Souleimanian, Naira, Deleavey, Glen F, Soifer, Harris, Wang, Sijian, Tiemann, Katrin, Damha, Masad J, Stein, Cy A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499694/
https://ncbi.nlm.nih.gov/pubmed/23344235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.35
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