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Selection of 2′-Deoxy-2′-Fluoroarabino Nucleic Acid (FANA) Aptamers That Bind HIV-1 Integrase with Picomolar Affinity

[Image: see text] Systematic Evolution of Ligands by Exponential Enrichment (SELEX) is the iterative process by which nucleic acids that can bind with high affinity and specificity (termed aptamers) to specific protein targets are selected. Using a SELEX protocol adapted for Xeno-Nucleic Acid (XNA)...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Rose, Kevin M., Alves Ferreira-Bravo, Irani, Li, Min, Craigie, Robert, Ditzler, Mark A., Holliger, Philipp, DeStefano, Jeffrey J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005942/
https://ncbi.nlm.nih.gov/pubmed/31560515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00237
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