Selection of 2′-Deoxy-2′-Fluoroarabino Nucleic Acid (FANA) Aptamers That Bind HIV-1 Integrase with Picomolar Affinity

[Image: see text] Systematic Evolution of Ligands by Exponential Enrichment (SELEX) is the iterative process by which nucleic acids that can bind with high affinity and specificity (termed aptamers) to specific protein targets are selected. Using a SELEX protocol adapted for Xeno-Nucleic Acid (XNA)...

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Détails bibliographiques
Publié dans:ACS Chem Biol
Auteurs principaux: Rose, Kevin M., Alves Ferreira-Bravo, Irani, Li, Min, Craigie, Robert, Ditzler, Mark A., Holliger, Philipp, DeStefano, Jeffrey J.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2019
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005942/
https://ncbi.nlm.nih.gov/pubmed/31560515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00237
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