Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids

Gymnosis is the process of the delivery of antisense oligodeoxynucleotides to cells, in the absence of any carriers or conjugation, that produces sequence-specific gene silencing. While gymnosis was originally demonstrated using locked nucleic acid (LNA) gapmers, 2′-deoxy-2′fluoroarabino nucleic aci...

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Detalhes bibliográficos
Main Authors: Souleimanian, Naira, Deleavey, Glen F, Soifer, Harris, Wang, Sijian, Tiemann, Katrin, Damha, Masad J, Stein, Cy A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499694/
https://ncbi.nlm.nih.gov/pubmed/23344235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.35
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