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2′-Deoxy-2′-fluoro-β-d-arabinonucleosides and oligonucleotides (2′F-ANA): synthesis and physicochemical studies
Recently, hybrids of RNA and d-arabinonucleic acids (ANA) as well as the 2′-deoxy-2′-fluoro-d-arabinonucleic acid analog (2′F-ANA) were shown to be substrates of RNase H. This enzyme is believed to be involved in the primary mechanism by which antisense oligonucleotides cause a reduction in target R...
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| Glavni autori: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2000
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC110742/ https://ncbi.nlm.nih.gov/pubmed/10982885 |
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