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2′-Deoxy-2′-fluoro-β-d-arabinonucleosides and oligonucleotides (2′F-ANA): synthesis and physicochemical studies

Recently, hybrids of RNA and d-arabinonucleic acids (ANA) as well as the 2′-deoxy-2′-fluoro-d-arabinonucleic acid analog (2′F-ANA) were shown to be substrates of RNase H. This enzyme is believed to be involved in the primary mechanism by which antisense oligonucleotides cause a reduction in target R...

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Detalhes bibliográficos
Main Authors: Wilds, Christopher J., Damha, Masad J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110742/
https://ncbi.nlm.nih.gov/pubmed/10982885
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