Synthesis and Properties of 2′-Deoxy-2′,4′-difluoroarabinose-Modified Nucleic Acids

We report the synthesis, thermal stability, and RNase H substrate activity of 2′-deoxy-2′,4′-difluoroarabino-modified nucleic acids. 2′-Deoxy-2′,4′-difluoroarabinouridine (2,′4′-diF-araU) was prepared in a stereoselective way in six steps from 2′-deoxy-2′-fluoroarabinouridine (2′-F-araU). NMR analys...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Org Chem
Main Authors: Martínez-Montero, Saúl, Deleavey, Glen F., Dierker-Viik, Arden, Lindovska, Petra, Ilina, Tatiana, Portella, Guillem, Orozco, Modesto, Parniak, Michael A., González, Carlos, Damha, Masad J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484724/
https://ncbi.nlm.nih.gov/pubmed/25723361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo502948t
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker