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Delivery of hexosaminidase A to the cerebrum after osmotic modification of the blood--brain barrier.
The present studies were undertaken to evaluate the possibility that hexosaminidase A, the enzyme deficient in Tay--Sachs disease, could be effectively delivered to brain. Previous studies from our laboratory have shown that hypertonic mannitol can be used to osmotically produce reversible disruptio...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
1981
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348880/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6946518/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.9.5838 |
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