Delivery of hexosaminidase A to the cerebrum after osmotic modification of the blood--brain barrier.

The present studies were undertaken to evaluate the possibility that hexosaminidase A, the enzyme deficient in Tay--Sachs disease, could be effectively delivered to brain. Previous studies from our laboratory have shown that hypertonic mannitol can be used to osmotically produce reversible disruptio...

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Main Authors: Neuwelt, E A, Barranger, J A, Brady, R O, Pagel, M, Furbish, F S, Quirk, J M, Mook, G E, Frenkel, E
Format: Artigo
Sprog:Inglês
Udgivet: 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC348880/
https://ncbi.nlm.nih.gov/pubmed/6946518
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