Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery.

The present study describes a canine model of transient reversible blood-brain barrier disruption with hyperosmolar mannitol infusion into the internal carotid artery. Studies in this model show that osmotic blood-brain barrier disruption before intracarotid infusion of methotrexate results in marke...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Neuwelt, E A, Maravilla, K R, Frenkel, E P, Rapaport, S I, Hill, S A, Barnett, P A
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1979
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC372166/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/457877/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109509
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