Delivery of hexosaminidase A to the cerebrum after osmotic modification of the blood--brain barrier.

The present studies were undertaken to evaluate the possibility that hexosaminidase A, the enzyme deficient in Tay--Sachs disease, could be effectively delivered to brain. Previous studies from our laboratory have shown that hypertonic mannitol can be used to osmotically produce reversible disruptio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Neuwelt, E A, Barranger, J A, Brady, R O, Pagel, M, Furbish, F S, Quirk, J M, Mook, G E, Frenkel, E
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 1981
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348880/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6946518/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.9.5838
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