In Silico Discovery of Androgen Receptor Antagonists with Activity in Castration Resistant Prostate Cancer

Previously available androgen receptor (AR) antagonists (bicalutamide, flutamide, and nilutamide) have limited activity against AR in prostate cancers that relapse after castration [castration resistant prostate cancer (CRPC)]. However, recent AR competitive antagonists such as MDV3100, generated th...

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Dades bibliogràfiques
Autors principals: Shen, Howard C., Shanmugasundaram, Kumaran, Simon, Nicholas I., Cai, Changmeng, Wang, Hongyun, Chen, Sen, Balk, Steven P., Rigby, Alan C.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2012
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487628/
https://ncbi.nlm.nih.gov/pubmed/23023563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1222
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