In Silico Discovery of Androgen Receptor Antagonists with Activity in Castration Resistant Prostate Cancer

Previously available androgen receptor (AR) antagonists (bicalutamide, flutamide, and nilutamide) have limited activity against AR in prostate cancers that relapse after castration [castration resistant prostate cancer (CRPC)]. However, recent AR competitive antagonists such as MDV3100, generated th...

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Main Authors: Shen, Howard C., Shanmugasundaram, Kumaran, Simon, Nicholas I., Cai, Changmeng, Wang, Hongyun, Chen, Sen, Balk, Steven P., Rigby, Alan C.
格式: Artigo
語言:Inglês
出版: Endocrine Society 2012
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487628/
https://ncbi.nlm.nih.gov/pubmed/23023563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1222
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