Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis

The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth-promoting functions during PCa development and progression through genetic and epigenetic mechanisms. Androgen deprivation ther...

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Veröffentlicht in:Oncogene
Hauptverfasser: Yuan, X, Cai, C, Chen, S, Yu, Z, Balk, SP
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4890635/
https://ncbi.nlm.nih.gov/pubmed/23752196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.235
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