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Androgen receptor targeting drugs in castration-resistant prostate cancer and mechanisms of resistance

Reactivated androgen receptor (AR) signaling drives castration-resistant prostate cancer (CRPC). Novel AR targeting drugs abiraterone and enzalutamide have improved survival of CRPC patients. However, resistance to these agents develops and patients ultimately succumb to CRPC. Potential mechanisms o...

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Veröffentlicht in:Clin Pharmacol Ther
Hauptverfasser: Crona, Daniel J., Milowsky, Matthew I., Whang, Young E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715745/
https://ncbi.nlm.nih.gov/pubmed/26331358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.256
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