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Intratumoral androgen biosynthesis in prostate cancer pathogenesis and response to therapy
The majority of prostate cancers (PCa) express high levels of androgen receptor (AR) and are dependent for their growth on testosterone produced by the testes, which is reduced in the prostate to the higher affinity ligand 5α-dihydrotestosterone (DHT). PCa growth can be suppressed by androgen depriv...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3815562/ https://ncbi.nlm.nih.gov/pubmed/21712345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-10-0339 |
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