In Silico Discovery of Androgen Receptor Antagonists with Activity in Castration Resistant Prostate Cancer

Previously available androgen receptor (AR) antagonists (bicalutamide, flutamide, and nilutamide) have limited activity against AR in prostate cancers that relapse after castration [castration resistant prostate cancer (CRPC)]. However, recent AR competitive antagonists such as MDV3100, generated th...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Shen, Howard C., Shanmugasundaram, Kumaran, Simon, Nicholas I., Cai, Changmeng, Wang, Hongyun, Chen, Sen, Balk, Steven P., Rigby, Alan C.
פורמט: Artigo
שפה:Inglês
יצא לאור: Endocrine Society 2012
נושאים:
Original Research
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487628/
https://ncbi.nlm.nih.gov/pubmed/23023563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1222
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