In Silico Discovery of Androgen Receptor Antagonists with Activity in Castration Resistant Prostate Cancer

Previously available androgen receptor (AR) antagonists (bicalutamide, flutamide, and nilutamide) have limited activity against AR in prostate cancers that relapse after castration [castration resistant prostate cancer (CRPC)]. However, recent AR competitive antagonists such as MDV3100, generated th...

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Bibliographische Detailangaben
Hauptverfasser: Shen, Howard C., Shanmugasundaram, Kumaran, Simon, Nicholas I., Cai, Changmeng, Wang, Hongyun, Chen, Sen, Balk, Steven P., Rigby, Alan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2012
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487628/
https://ncbi.nlm.nih.gov/pubmed/23023563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1222
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