Evidence for pH-Dependent Protease Activity in the Adeno-Associated Virus Capsid

Incubation of highly purified adeno-associated virus (AAV) capsids in vitro at pH 5.5 induced significant autocleavage of capsid proteins at several amino acid positions. No autocleavage was seen at pH 7.5. Examination of other AAV serotypes showed at least two different pH-induced cleavage patterns...

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Detaylı Bibliyografya
Asıl Yazarlar: Salganik, Maxim, Venkatakrishnan, Balasubramanian, Bennett, Antonette, Lins, Bridget, Yarbrough, Joseph, Muzyczka, Nicholas, Agbandje-McKenna, Mavis, McKenna, Robert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2012
Konular:
Structure and Assembly
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486322/
https://ncbi.nlm.nih.gov/pubmed/22915820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01717-12
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